Prof. Dr. Rasmus Linser

Structure and dynamics are usually what determines the function of a protein in the cell. Even though one of the two can sometimes play a more important role than the other, or only a transient structure is formed in the course of protein interactions, only the combination of both provides a faithful representation of the molecular behavior. Nuclear Magnetic Resonance (NMR) spectroscopy is able to deliver information on both such parameters in a range of molecular sizes and dynamics time scales. Structural information is obtained by a characterization of chemical shifts, interatomic distances, and the size and direction of other interactions, whereas dynamics are mostly represented by the lifetimes of different non-equilibrium states in addition to internuclear interactions. The Linser group develops and uses state-of-the-art NMR spectroscopic tools for the understanding of protein structural and dynamic features that govern their functionality. We employ both, solid-state NMR as well as solution NMR spectroscopy, both in terms of method development and applications. One of our major foci is to use the rich information content of protons for solid-state NMR purposes, i. e. unambiguous resonance assignment, protein structure, and protein dynamics, but there are many more topics of interest, and many more ways in which NMR can solve biological questions. As we are still expanding our group please do not hesitate to contact us for current opportunities to join the team.

See an article about activities regarding protein dynamics in our Group (German).

See our (overview) Accounts paper on "Protons in Solid-State NMR"!

See Rasmus presenting our work in the MIT Boston Zoominar (10.05.22).

Oral presentation of our research in the recent ICMRBS seminar series (second talk, from minute 39.21)!

See a short article about solid-state NMR relaxation activities of our Group (German).

Julia's and Bendedikt's paper on the ring flip within a bound ligand is accepted!

Julia is now Dr. Kotschy! Congratulations, Julia!

Katja is now Dr. Burakova! Congratulations, Katja!

Alex' paper on efficient 5D strategies is finally out!